Publications

2024

Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion

Anaguano D., Opeoluwa A-f., Vick G.S., Yanik S., Blauwkamp J., Fierro M.A., Absalon S., Srinivasan P., and muralidharan v. plos biology | Biorxiv preprint

Highlighted: prelights (preprint highlights selected by the biological community)

UGA Research News

2023

Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors

Anaguano D., Dedkhad w., Brooks C.F., Cobb D.W., and Muralidharan V. Journal of cell science | BioRxiv preprint

Highlighted: Interview with the first author (Dr. Anaguano)

Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

Liffner B., Cepeda diaz a.k., blauwkamp j., anaguano d., frölich s., muralidharan v., wilson d.w., dvorin j., and absalon s. elife | BIorxiv preprint

2021

Some conditions apply: Systems for studying plasmodium falciparum protein function

Kudyba H.M.*, Cobb D.W.*, Vega-Rodríguez j., and Muralidharan v. plos Pathogens (*– equal contributions)

A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites

COBB D.W., KUDYBA H.M., VILLEGAS A., HOOPMANN M.R., BAPTISTA R.P., BRUTON B., KRAKOWIAK M., MORITZ R.L. AND MURALIDHARAN V. PLOS PATHOGENS | BIORXIV PREPRINT

2020

plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the clp proteolytic system

FLORENTIN A., STEPHENS D.R., BROOKS C.F., BAPTISTA R.P. AND MURALIDHARAN V. PROCEEDINGS OF THE NATIONAL Academy of Sciences | BIORXIV PREPRINT

DIRECTING TRAFFIC: CHAPERONE-MEDIATED PROTEIN TRANSPORT IN MALARIA PARASITES

FLORENTIN A., COBB D.W., KUDYBA H.M. AND MURALIDHARAN V. CELLULAR MICROBIOLOGY

An endoplasmic reticulum crec family protein regulates the egress proteolytic cascade in malaria parasites

fierro m.a., asady b., brooks c.f., cobb d.w., villegas a., moreno s.n.j. and muralidharan v. MBIO | BIORXIV PREPRINT

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

Zimbres F.M., Valenciano A.L., Merino E.F., Florentin A., Holderman N.R., He G., Gawarecka K., Skorupinska-Tudek K., Fernández-Murga M.L., Swiezewska E., Wang X., Muralidharan V., AND Cassera M.B. SCIENTIFIC REPORTS | BIORXIV PREPRINT

2019

The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

Kudyba M.H., Cobb D.W., Fierro M.A., Florentin A., Ljolje D., Singh D., Lucchi N.W., and Muralidharan V. CellULAR MicrobiolOGY | BIORXIV PREPRINT

Field evaluation of malaria malachite green loop-mediated isothermal amplification in health posts in Roraima state, Brazil

Kudyba H.M., Louzada J., Ljolje D., Kudyba K.A., Muralidharan V., Oliveira-Ferreira J. AND Lucchi N.W. MALARIA JOURNAL

2018

CRISPR/Cas9 gene editing to make conditional mutants of the human malaria parasite, P. falciparum

Kudyba M.H.*, Cobb D.W.*, Florentin A., Krakowiak M., and Muralidharan v. (*– Equal Contributions) JOURNAL OF visALIZED expERIMENTS | BIORXIV PREPRINT

2017

PfClpC is an essential Clp chaperone required for plastid integrity and Clp protease stability in Plasmodium falciparum

Florentin A., Cobb D.W., Fishburn J.D., Cipriano M.J., Kim P.S., Fierro M.A., Striepen B., and Muralidharan V. (2017) Cell Reports | BIORXIV PREPRINT

Plasmodium-specific exported chaperone, PfHsp70x is dispensable for parasite growth

Cobb D.W.*, Florentin A.*, Fierro M.A., Krakowiak M., Moore J.M., and Muralidharan V. (*– Equal Contributions) mSphere | BIORXIV PREPRINT

In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites

Szajnman S.H., Galaka T., Li Z.H., Li C., Howell N.M., Chao M.N., Striepen B., Muralidharan V., Moreno S.N., AND Rodriguez J.B. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2015

Teaching old drugs new tricks to stop malaria invasion in its tracks

Muralidharan V. AND Striepen B. BMC BIOLOGY

The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism

Flaherty B.R., Wang Y., Trope E.C., Ho T.G., Muralidharan V., Kennedy E.J., AND Peterson D.S. PLOS ONE

2014

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

Beck J.R.*, Muralidharan V.*, Oksman A., AND Goldberg D.E. (*– Equal Contributions) NATURE

2013

Asparagine repeats in Plasmodium falciparum proteins: good for nothing?

Muralidharan V. and Goldberg D.E. PLoS Pathogens

2012

Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

Muralidharan V., Oksman A., Pal P., Lindquist S., and Goldberg D.E. NATURE COMMUNICATIONS

2011

Tuning protein autoinhibition by domain destabilization

Cho J.H., Muralidharan V., Vila-Perello M., Raleigh D.P., Muir T.W. and, Palmer AG 3rd. NATURE STRUCTURAL AND MOLECULAR BIOLOGY

Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag

Muralidharan V., Oksman A., Iwamoto M., Wandless T.J., and Goldberg D.E. PROCEEDINGS OF THE NATIONAL Academy of Sciences

2010

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

Russo I., Babbitt S.*, Muralidharan V.*, Butler T., Oksman A., and Goldberg D.E. (*– EQUAL CONTRIBUTIONS) NATURE

2006

Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II

Muralidharan V.*, Dutta K.*, Cho J., Vila-Perello M., Raleigh D.P., Cowburn D., AND Muir T.W. (*– EQUAL CONTRIBUTIONS) BIOCHEMISTRY

Protein ligation: an enabling technology for the biophysical analysis of proteins

Muralidharan V. AND Muir T.W. NATURE METHODS

2004

Domain-specific incorporation of noninvasive optical probes into recombinant proteins

Muralidharan V., Cho J., Trester-Zedlitz M., Kowalik L., Chait B.T., Raleigh D.P., AND Muir T.W. JOURNAL OF THE American Chemical Society